BI2BPB5-Physiological Biochemistry

Module Provider: School of Biological Sciences
Number of credits: 20 [10 ECTS credits]
Level:5
Terms in which taught: Spring term module
Pre-requisites: BI1MB2 Metabolic Biochemistry or BI1BAB2 Metabolic and Practical Biochemistry
Non-modular pre-requisites:
Co-requisites:
Modules excluded:
Current from: 2022/3

Module Convenor: Dr Francoise Mazet
Email: f.m.mazet@reading.ac.uk

Type of module:

Summary module description:

This module takes the cellular biochemical concepts covered in part 1 and links this to understanding how biochemistry affects the functions of tissues and organs of the body, whether this be in health or disease. The lecture content will discuss the biochemistry of different organ systems/bodily processes and how biochemical actions dictate physiological outcomes (for example how does a working muscle use different fuels for different tasks). The focus of this module is therefore how cellular biochemistry produces organ system changes and their physiological outcomes. The practicals will focus on the technical application of biochemistry to study the enzymes of the liver and how this can be used to diagnose disease.

Aims:

This module aims to provide the student with an understanding of metabolism and cell communication of the organs and tissues of the body through application of key concepts to the in-depth study of the biochemistry of selected organ systems (for example endocrine, liver, muscle and brain). Finally, students will acquire an appreciation of the integrated nature of biochemistry across organ systems and the body, and how this can be altered in pathology. 

Assessable learning outcomes:

By the end of the module it is expected that the student will be able to:

• Describe the principles of metabolism, metabolic pathways and their control, and enzyme kinetics.


• Discuss the key concepts of how cells communicate, and using hormone/neurotransmitters as examples describe their synthesis, release, transport, cellular effects and inactivation.


• Differentiate the role of biochemical pathways in selected organ systems (e.g. endocrine, liver, muscle and brain)


• Recognise the role of biochemical processes in the integration of physiology of the human body: “molecules to physiology”.


• Develop and test scientific methodologies of own design and reflect on adjustments needed to obtain a feasible methodology. 


• Discuss how practical biochemistry can be used to study enzymatic processes and its use in diagnosing disease. 

Additional outcomes:

1. Develop skills in designing and testing scientific methodology of own design. 


2. Gain experience working with in the lab with protocols that need refinement, rather than being pre-determined.


3. Develop skills in distributing and managing work alongside other members of the group to work towards a set goal. 

Outline content:

This module will provide fundamental knowledge of the biochemical processes of the human body and its organ systems, as well as the cellular and metabolic processes that underpin these physiological effects. Through the lectures/seminars/practicals in this module the following content will be discussed:

• Metabolism and its organisation/enzymes, as well as principles of energy generation.


• The principles of metabolic control (enzymes, substrates,inhibitors and genes)


• How cells communicate through signalling molecules (e.g. hormones)


• How signalling molecules are synthesised, stored, released, transported, responded to and destroyed.


• The role and nature of biochemical processes in selected human organ systems


• Practical investigation of enzymes

Brief description of teaching and learning methods:

There will be 20 ~50 minute lectures (divided by a short break) each week and 3 x 1 hour tutorials. There will also be 4 x 2 hour practical sessions. Additionally, students will be expected to use their free time to engage in background reading.

Contact hours:

	Autumn	Spring	Summer
Lectures		20
Seminars		3
Practicals classes and workshops		8
Guided independent study:		169
Total hours by term		200
Total hours for module	200

Summative Assessment Methods:

Method	Percentage
Written exam	50
Set exercise	50

Summative assessment- Examinations:

One-and-a half-hours

Summative assessment- Coursework and in-class tests:

Set exercise, 50%

Formative assessment methods:

Penalties for late submission:

The Support Centres will apply the following penalties for work submitted late:

• where the piece of work is submitted after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for that piece of work will be deducted from the mark for each working day (or part thereof) following the deadline up to a total of five working days;
• where the piece of work is submitted more than five working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

The University policy statement on penalties for late submission can be found at: https://www.reading.ac.uk/cqsd/-/media/project/functions/cqsd/documents/cqsd-old-site-documents/penaltiesforlatesubmission.pdf
You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.

Assessment requirements for a pass:

A mark of 40% overall

Reassessment arrangements:

August - September re-examination

Additional Costs (specified where applicable):

1) Required text books:  Essential Physiological Biochemistry (~£40), also available as an E-book through the library. 

2) Specialist equipment or materials:  None

3) Specialist clothing, footwear or headgear:  None

4) Printing and binding:  None

5) Computers and devices with a particular specification:  None

6) Travel, accommodation and subsistence:  None

Last updated: 22 September 2022